What is Stevens-Johnson Syndrome?
Stevens-Johnson
syndrome ( SJS ) is a severe blistering rash affecting both skin and mucous
membranes. The majority of cases have been attributed to drug exposures.
The reaction begins with burning and painful lesions on the face and upper torso
and extends to the rest of the body. Blistering and epidermal detachment may
occur.
Patients may present with fever, malaise, myalgia and ocular manifestations.
Mortality has been estimated at 5% of cases.
From Jan. 1, 1973, to Feb. 21, 2005, Health Canada received 4 reports of SJS
suspected of being associated with Ibuprofen. At the time of reporting, 3
patients had not recovered, and the outcome was unknown for 1 patient. The
reports involved patients aged 13 to 34 years and were all received after April
2001. The dosages ranged from 200 mg to 1200 mg daily. The onset of reactions
varied from the day of administration to approximately 15 days after starting
Ibuprofen. In one report, Carbamazepine was indicated as a suspect drug along
with Ibuprofen.
Source:
Health Canada.
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