What is Stevens-Johnson Syndrome?

Stevens-Johnson syndrome ( SJS ) is a severe blistering rash affecting both skin and mucous membranes. The majority of cases have been attributed to drug exposures.
The reaction begins with burning and painful lesions on the face and upper torso and extends to the rest of the body. Blistering and epidermal detachment may occur.
Patients may present with fever, malaise, myalgia and ocular manifestations. Mortality has been estimated at 5% of cases.

From Jan. 1, 1973, to Feb. 21, 2005, Health Canada received 4 reports of SJS suspected of being associated with Ibuprofen. At the time of reporting, 3 patients had not recovered, and the outcome was unknown for 1 patient. The reports involved patients aged 13 to 34 years and were all received after April 2001. The dosages ranged from 200 mg to 1200 mg daily. The onset of reactions varied from the day of administration to approximately 15 days after starting Ibuprofen. In one report, Carbamazepine was indicated as a suspect drug along with Ibuprofen.

Source: Health Canada.